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P1‐076: Involvement of paraoxonase 1 (PON‐1) genetic variants in Alzheimer pathophysiology
Author(s) -
Théroux Louise,
Leduc Valerie,
Poirier Judes
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.624
Subject(s) - pon1 , paraoxonase , medicine , allele , disease , oncology , endocrinology , genotype , biology , genetics , gene , oxidative stress
Currently data from 119 mitochondrial polymorphisms were extracted from GWAS data from 500 Alzheimer’s disease patients and 300 individuals diagnosed as cognitively normal. Polymorphism data for all mitochondrial genes will be combined into a composite score from the entire mitochondria to assess mitochondrial genetic load. This genetic load score will be included in a logistic regression to assess potential associations between mitochondrial gene variants and the development or progression of Alzheimer’s disease. Conclusions: Genetic variation within the mitochondria electron transport chain may impact the development or progression of Alzheimer’s disease.