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P1‐018: The mental activity and exercise (MAX) trial: A randomized, controlled trial to enhance cognitive function in older adults with cognitive complaints
Author(s) -
Barnes Deborah E.,
Poelke Gina,
Kramer Arthur F.,
Castro Cynthia,
King Abby,
Yaffe Kristine
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.565
Subject(s) - randomized controlled trial , cognition , psychological intervention , physical therapy , psychology , aerobic exercise , medicine , clinical psychology , audiology , psychiatry
would be better than just <140mmHg for improving their cardiovascular prognosis in younger (>50years) patients with hypertension, we think that a bifactorial randomization would be cost-effective to prove the independent role of both BP lowering and of specific dementia protective properties of AT1RBs. The issue remains the choice of the SBP targets in older populations as in HYVET and VA cohort. We propose to take<145mmHg as in HYVET for the upper one and <135mmHg for the lower, the difference being achieved thanks to a combination of thiazide and dihydropyridine at increasing dose. Conclusions: By establishing optimal drug class and optimal BP target, this bifactorial trial design should establish optimal prevention of dementia by antihypertensive drugs.