Premium
F5‐03‐01: High‐frequency remote cognitive assessment in the Home‐Based Assessment study
Author(s) -
Hayes Tamara
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.540
Subject(s) - test (biology) , audiology , cognitive test , recall , cognition , demographics , dementia , psychology , medicine , demography , cognitive psychology , psychiatry , disease , sociology , biology , paleontology
occlusive disease of the carotid artery and prevent stroke; however, microemboli evident on MRI diffusion weighted imaging (DWI) can occur. This is the first study to apply permutation likelihood analysis (PLA), an image-based variant of the anatomic likelihood analysis (ALE). ALE statistics assess concordance among a series of points, typically in meta-analytic studies of voxel-based morphometry (Glahn et al. 2008; Ellison-Wright et al. 2008). Here, the goal is to characterize the distribution of microemboli. Methods: Patients were imaged within two weeks presurgically and within 48 hours postsurgically and 81 were determined to have new onset microemboli. Microemboli regions of interest (ROI) were manually defined (MRICron) based on DWI and Apparent diffusion coefficient (ADC) images by two raters, a board certified neuroradiologist with experience detecting numbers of microemboli (B.L.) and a novice rater (D.D.) trained to adequate interrater reliability with respect to microembolus volume (R21⁄4 .99) and spatial overlap (similarity index 1⁄4 .80; Dinishak et al. 2009). ADC images and ROIs were normalized using SPM5. Because laterality was largely determined by side of procedure, ROIs were collapsed across hemispheres using FSL and SPM5. ROIs were smoothed using a conservative Gaussian distribution (FWHM 1⁄4 6mm) with FSL and input to the PLA. Results: Areas with a high degree of convergence across ROIs included the anterior and posterior cingulate, middle frontal gyrus, insula, basal ganglia, and occipital areas (Brodmann areas 18 and 19). Conclusions: Regions vulnerable to microemboli include those implicated in executive control and motor planning/ speeded responses (anterior cingulate, middle frontal gyrus, basal ganglia) and memory (posterior cingulate), functions commonly affected in Alzheimer’s disease. Other regions support processes that typical cognitive batteries rarely assess (occipital, insula) and merit further investigation.