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F5‐02‐01: Cerebrospinal fluid ß‐amyloid 42 and tau proteins as biomarkers of Alzheimer‐type pathologic changes in the brain
Author(s) -
Herukka Sanna-Kaisa,
Soininen Hilkka
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.534
Subject(s) - cerebrospinal fluid , pathology , biomarker , medicine , dementia , atrophy , neuropathology , immunohistochemistry , alzheimer's disease , amyloid (mycology) , tau protein , amyloid beta , vascular dementia , disease , chemistry , biochemistry
Results: Cerebrospinal fluid A 42 and tau protein levels were related to amyloid load and the presence of neurofibrillary pathologic abnormalities in the brain. Cerebrospinal fluid A 42 level correlated inversely with total A load in the brain, and CSF tau level correlated with results of immunohistochemistry for hyperphosphorylated tau and with the presence of neocortical neurofibrillary tangles. In multivariate logistic regression analysis, the number of neuritic plaques in the brain remained a significant predictor of decreased CSF A 42 level and of increased CSF tau level. Based on the ratio of phosphorylated tau level to A 42 level, sensitivity was 91.6%, and specificity was 85.7%, with an overall accuracy of 90.2% for the presence of pathologic neuritic plaque in the brain.