Premium
S5‐01‐04: Molecular interplay between mTOR, Aβ and tau: Effects on cognitive impairments
Author(s) -
Oddo Salvatore
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.519
Subject(s) - pi3k/akt/mtor pathway , autophagy , neuroscience , mechanistic target of rapamycin , cognition , signal transduction , disease , biology , psychology , microbiology and biotechnology , medicine , genetics , apoptosis
not available. S5-02-02 NETWORKS OF REGIONAL COVARIANCE IN MRI GRAY MATTER: REPRODUCIBLE MULTIVARIATE PATTERNS IN ALZHEIMER’S DISEASE, MILD COGNITIVE IMPAIRMENT AND HEALTHY AGING Gene E. Alexander, University of Arizona, Tucson, AZ, USA. Contact e-mail: gene.alexander@arizona.edu Background: Neuroimaging studies with magnetic resonance imaging (MRI) have typically relied on univariate analysis methods to investigate regional brain changes associated with healthy aging, Alzheimer’s disease (AD), and the increased risk for AD with mild cognitive impairment (MCI). Multivariate network analyses can test for neuroimaging patterns of spatial covariance, identifying brain changes as network interactions in aging and disease (Alexander and Moeller, 1994). Objective: To demonstrate multivariate network patterns of MRI gray matter that differentially