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S5‐01‐03: Tau‐targeted treatment of Alzheimer's disease and related disorders
Author(s) -
Ittner Lars M.,
Ke Yazi D.,
Eersel Janet,
Gladbach Amadeus,
Staufenbiel Matthias,
Hovens Christopher,
Gotz Jurgen
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.518
Subject(s) - hyperphosphorylation , protein phosphatase 2 , genetically modified mouse , tau protein , alzheimer's disease , phosphatase , tauopathy , amyloid (mycology) , bace1 as , transgene , phosphorylation , amyloid precursor protein , chemistry , biology , pathology , microbiology and biotechnology , medicine , biochemistry , neurodegeneration , disease , gene
not available. S5-02-02 NETWORKS OF REGIONAL COVARIANCE IN MRI GRAY MATTER: REPRODUCIBLE MULTIVARIATE PATTERNS IN ALZHEIMER’S DISEASE, MILD COGNITIVE IMPAIRMENT AND HEALTHY AGING Gene E. Alexander, University of Arizona, Tucson, AZ, USA. Contact e-mail: gene.alexander@arizona.edu Background: Neuroimaging studies with magnetic resonance imaging (MRI) have typically relied on univariate analysis methods to investigate regional brain changes associated with healthy aging, Alzheimer’s disease (AD), and the increased risk for AD with mild cognitive impairment (MCI). Multivariate network analyses can test for neuroimaging patterns of spatial covariance, identifying brain changes as network interactions in aging and disease (Alexander and Moeller, 1994). Objective: To demonstrate multivariate network patterns of MRI gray matter that differentially