O4‐07‐08: Design of selective estrogen receptor modulators as neuroprotective and procognitive agents | Zendy

Thatcher Gregory R.J. | Zendy; Abdelhamid Ramy | Zendy; Luo Jia | Zendy; Qin Zhihui | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

O4‐07‐08: Design of selective estrogen receptor modulators as neuroprotective and procognitive agents

Author(s) -

Thatcher Gregory R.J.,

Abdelhamid Ramy,

Luo Jia,

Qin Zhihui

Publication year - 2010

Publication title -

alzheimer's and dementia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.713

H-Index - 118

eISSN - 1552-5279

pISSN - 1552-5260

DOI - 10.1016/j.jalz.2010.05.511

Subject(s) - selective estrogen receptor modulator , neuroprotection , raloxifene , pharmacology , estrogen receptor , estrogen , chemistry , medicine , endocrinology , cancer , breast cancer

(OR 0.28 [95% CI, 0.10-0.80] for dementia; OR 0.58 [95% CI, 0.38-0.89] for cognitive impairment) and among normal-weight men (OR 0.34 [95% CI, 0.14-0.83] for dementia and OR 0.56 [95% CI, 0.37-0.84] for cognitive impairment). The low-risk profile was associated with a decreased OR for dementia (OR 0.38 [95% CI, 0.19-0.77]) among men without the APOE e4 allele, but not among men with 1 or 2 alleles. Conclusions: In this population, having a healthy lifestyle in midlife reduced the risk of dementia in late life.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research