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O3‐06‐05: Comparison of biomarkers for the prediction of cognitive decline
Author(s) -
Villemagne Victor L.,
Chetelat Gael,
Pike Kerryn,
Jones Gareth,
Ellis Kathryn,
Li Qiao-Xin,
Mulligan Rachel,
Ackermann Uwe,
O'Keefe Graeme,
Martins Ralph,
Ames David,
Masters Colin L.,
Rowe Christopher
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.431
Subject(s) - episodic memory , neuroimaging , posterior cingulate , alzheimer's disease neuroimaging initiative , dementia , cognitive decline , medicine , effects of sleep deprivation on cognitive performance , pittsburgh compound b , apolipoprotein e , cognition , memory clinic , oncology , alzheimer's disease , psychology , disease , neuroscience
diffusion magnetic resonance imaging (MRI) at 3Tesla. The MRI data was analysed using Freesurfer (v4.4.0) to segment cortical and subcortical brain region volumes, which were then registered to the diffusion data. Linear regression models were used to assess differences in the volume and diffusion indices of subcortical brain regions between PSEN1 MCs and controls. Results: After adjusting for gender, age and total intracranial volume, MCs demonstrated significantly smaller volumes of the left caudate by 0.67ml (95%CI 0.29,1.06 p 1⁄4 0.002) adjacent left accumbens area by 0.13ml (95%CI 0.05,0.21 p 1⁄4 0.003) and right caudate by 0.51ml (95%CI 0.12,0.89 p 1⁄4 0.015). There was weaker evidence for a reduction in the volume of the left putamen by 0.45ml (95%CI -0.08,0.97 p 1⁄4 0.092), right putamen by 0.41ml (95%CI -0.05,0.87, p 1⁄4 0.075), left thalamus by 0.54ml (95%CI -0.04,1.11, p 1⁄4 0.065), right thalamus by 0.38ml (95%CI -0.17,0.94, p 1⁄4 0.160) and right accumbens area by 0.10ml (95%CI -0.01,0.20, p 1⁄4 0.061). The only subcortical region demonstrating evidence of a difference in diffusivity between MCs and controls was the right thalamus, where MCs showed a reduction in axial diffusivity of 55.0mm2/s (95%CI -2,112 p 1⁄4 0.059), radial diffusivity of 41.0mm2/s (95%CI -5,87 p 1⁄4 0.077) and mean diffusivity (MD) of 45.7mm2/s (95%CI -3,94 p 1⁄4 0.062). Within the group of PSEN1 MCs, increasing thalamic MD correlated with decreasing mini-mental state examination (MMSE) score. Conclusions: The early striatal and thalamic amyloid deposition witnessed in PSEN1 MCs is accompanied by reduced volumes of these brain regions. In the right thalamus, increased diffusivity indices suggest loss of tissue microstructural integrity and this appears to be associated with deteriorating cognitive function. O3-06-04 BASELINE AND FOLLOW-UP NEUROIMAGING RESULTS FROM THE AUSTRALIAN IMAGING, BIOMARKER, AND LIFESTYLE FLAGSHIP STUDY OF AGING (AIBL) Christopher C. Rowe, Kathryn Ellis, Gael Chetelat, Kerryn Pike, Miroslava Rimajova, Cassandra Szoeke, Pierrick Bourgeat, Olivier Salvado, Ralph Martins, Colin L. Masters, David Ames, Victor L. Villemagne, AIBL Research Group,Austin Hospital, Melbourne, Australia; Department of Psychiatry, University of Melbourne, Melbourne, Australia; Edith Cowan University, Perth, Australia; CSIRO ICT Centre, Brisbane, Australia; The Mental Health Research Institute, Melbourne, Australia; National Ageing Research Institute, Melbourne, Australia. Contact e-mail: Christopher.ROWE@austin.org.au