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O3‐02‐02: Identifying factors that moderate the onset and rate of prodromal cognitive impairment in dementia
Author(s) -
MacDonald Stuart W.S.,
Thorvaldsson Valgeir,
Johansson Boo,
Bäckman Lars
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.398
Subject(s) - cognitive decline , dementia , psychology , cognition , normative , population , demography , gerontology , audiology , developmental psychology , medicine , psychiatry , disease , philosophy , epistemology , sociology
healthy controls with respect to confrontation naming and semantic fluency (controlling for anxiety and depression scores and estimated premorbid intellectual capacity). When compared with NMCs at baseline, there was a trend for a significantly higher proportion of healthy controls defined as MCs at baseline to convert to the clinical diagnostic category of Mild Cognitive Impairment (MCI; objective functional impairment) 18 months later at followup (1.3% NMCs vs. 3.8% MCs). PIB PET analysis performed on n 1⁄4 81 NMCs and n 1⁄4 91 MCs at baseline showed that there was no significant difference in the proportion of NMCs and MCs above a designated threshold of brain amyloid deposition (33% NMCs vs. 30% MCs). Conclusions: Taken together, these findings have important implications for how we should conceptualize memory complaints vs. objective neuropsychological and neuroimaging findings in those over the age of 60. More specifically, subjective perception of memory status may a useful adjunct to other findings when seeking to identify those most at risk of age-related cognitive change.