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O2‐06‐06: The obesity related gene, FTO, increases the risk for incident Alzheimer's disease in a prospective population based study
Author(s) -
Graff Caroline,
Keller Lina,
Xu Weili,
Wang Hui-Xin,
Winblad Bengt,
Fratiglioni Laura
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.343
Subject(s) - dementia , medicine , apolipoprotein e , body mass index , vascular dementia , prospective cohort study , population , diabetes mellitus , disease , cohort , cohort study , oncology , endocrinology , environmental health
based on medical records, hypoglycaemic medication use, and random blood glucose level 11.0 mmol/l. Prediabetes was defined as random blood glucose level of 7.8-11.0 mmol/l in diabetes-free participants. Data were analyzed using standard and time-dependent Cox models. Results: During the 9-year follow-up, in the cognitively intact cohort, 182 people developed MCI (42 aMCI and 140 CIND), and 212 developed dementia; in the MCI cohort, 155 persons progressed to dementia. Diabetes and prediabetes led to a multi-adjusted hazard ratio of 3.64 (95% CI, 2.05-6.45) for the risk of dementia in subjects with MCI, and accelerated the progression from MCI to dementia by 2.33 years. Neither cross-sectional nor longitudinal association between diabetes and MCI was observed. Conclusions: Diabetes and prediabetes triple the risk of progression to dementia and anticipate dementia occurrence by more than two years in people with MCI. The lack of association between diabetes and the risk of MCI in our study suggests that diabetes might lead to dementia bypassing MCI or shortening the MCI phase in old people.