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O2‐05‐08: The anaemic neuron in Alzheimer disease, Parkinson's disease and dementia with Lewy bodies
Author(s) -
Ferrer Isidro
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.337
Subject(s) - dementia with lewy bodies , lewy body , neuroscience , parkinson's disease , substantia nigra , pathology , pars compacta , biology , neuron , hippocampus , dementia , medicine , disease
logistic regressions. We used an interaction to examine the effect of age and receiver operating characteristic (ROC) analysis to evaluate the predictive value of the model. Results: Of the participants, 56% were female, 18% were 90 years, and 82% had a diagnosis of AD. All neuropathological features except large infarcts and lacunes were positively associated with AD. The relationship between most neuropathological features and AD was attenuated in the oldest old compared to the young-old. Correspondingly, the predictive value of the model with all neuropathic features included was worse in the oldest old (ROC area under the curve, 95% confidence interval: 0.83, 0.79-0.87) compared to young old (0.92, 0.89-0.96). Conclusions: Neuropathological features appear to be less predictive of AD in the oldest old compared to the young old. The explanations for this difference are not clear but may be attributed to survival bias, different biology, or genetic factors.