Premium
O2‐04‐08: Progression of metabolic decline and amyloid deposition in Alzheimer's disease (AD) and their regional relation to a functional connectivity network in healthy controls
Author(s) -
Förster Stefan,
Grimmer Timo,
Miederer Isabelle,
Henriksen Gjermund,
Yousefi Behrooz,
Greve Doug,
Graner Philip,
Wester Hans-Jürger,
Förstl Hans,
Kurz Alexander,
Dickerson Brad,
Bartenstein Peter,
Drzezga Alexander
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.329
Subject(s) - disease , amyloid (mycology) , relation (database) , neuroscience , alzheimer's disease , medicine , gerontology , psychology , pathology , computer science , database
matching task to assess visual spatial function. A second level joint independent component analysis (jICA) on normalized MRI derived maps of GM concentration and fMRI contrast images of brain activation during either location matching or face matching was conducted. Results: For the combined fMRI face matching and GM analysis, the loading parameters were significantly higher in HC compared to AD for one component. Higher activation of that component in HC was observed within the occipital lobe, inferior temporal and frontal lobe, and cerebellar regions but relatively lower activity within the parietal lobe and the superior temporal gyrus. These differences in the fMRI component were associated with higher GM concentration in HC primarily within subcortical regions and hippocampus/parahippocampus. For the location matching vs. GM analysis, HC had significantly higher loading parameters on a component that spanned a network including ventral frontal, fusiform gyrus, parietal and subcortial structures and relatively lower activity within the superior frontal gyri and superior/middle temporal gyri. These functional changes were associated with GM differences again in subcortical, medial temporal and cingulate brain regions. When the joint components between face and location matching were examined in a jICA analysis, there was a frontal shift of activation present across both tasks in AD when compared to HC. Conclusions: The multimodal fusion analysis revealed AD-specific, grey matter atrophy associated pattern of functional visual network changes that may serve compensatory processes. Future studies are needed to identify how these structural-functional correlates of basic visual processes relate to cognitive deficits in AD.