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S2‐03‐01: Splicing and dicing in APP processing: Targeting proteases and mRNAs that regulate A‐beta production
Author(s) -
Wolfe Michael S.
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.285
Subject(s) - amyloid precursor protein secretase , rna splicing , alternative splicing , proteolysis , proteases , gamma secretase , gene isoform , chemistry , microbiology and biotechnology , biochemistry , amyloid precursor protein , biology , enzyme , gene , rna , medicine , disease , alzheimer's disease , pathology
in relation to MCI conversion differed among clinical variables: Deceleration in gait speed occurred over a decade before the transition to MCI, followed by the acceleration in decline in neuropsychological tests and expansion in ventricular volume, the latter occurring about 3 to 4 years before the transition. Our exploratory analysis using quantile regression models, which focuses on multi-factorial changes within individuals, appears to be a useful and valid method to elucidate potential physiological mechanisms occurring during the pre-symptomatic phase of dementia. Conclusions: Understanding the order and combinations of intra-individual changes associated with transition to MCI is fundamental to recognition of meaningful change and the pathophysiological pathways underlying developing dementia. These data can ultimately be applied over time to help clinicians in the early identification of dementia and to institute early treatment strategies.