Premium
O1‐05‐06: Apathy and depression in Alzheimer's disease and mild cognitive impairment: Occurrence and association with disease progression
Author(s) -
Palmer Katie,
Di Iulio Fulvia,
Caltagirone Carlo,
Spalletta Gianfranco
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.238
Subject(s) - apathy , depression (economics) , hazard ratio , confounding , medicine , psychiatry , disease , logistic regression , proportional hazards model , cognitive decline , alzheimer's disease , psychology , dementia , confidence interval , economics , macroeconomics
dementia, whereas of the 271 MCI subjects with out depression, 59 (21.8%) developed incident dementia. Out of 60 MCI subjects with apathy, 22 (36.7%) developed incident dementia, whereas of the 298 MCI subjects with out apathy, 67 (22.5%) developed incident dementia.After adjusting for age, sex, education (years) and Charlson index, the HR (95% CI) for incident dementia in MCI with apathy was 1.99[(1.21, 3.27) p 1⁄4 0.007]; and for MCI with depression was 1.66 [(1.06, 2.61) p 1⁄4 0.028]. Conclusions: Both apathy and depression significantly predicted the progression from MCI to incident dementia; however, the HR and level of significance are stronger for apathy.