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O1‐03‐05: Micro RNA‐125b (miRNA‐125b) functions in gliosis and glial cell proliferation: Significance to Alzheimer's disease
Author(s) -
Lukiw Walter J.,
Cui Jian Guo,
Culicchia Frank,
Zhao Yuhai
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.221
Subject(s) - astrogliosis , gliosis , biology , microrna , astrocyte , glial fibrillary acidic protein , microbiology and biotechnology , human brain , neurodegeneration , cell growth , cancer research , immunology , neuroscience , pathology , central nervous system , medicine , genetics , disease , gene , immunohistochemistry
analyzed. A lod score of 4.5 was calculated under a dominant model on chromosome 3 at rs10510224, which is in CNTN4, encoding a neuronal membrane protein. Under the dominant model, 5 additional SNPs, on chromosomes 6 and 1, had lod scores >4.0. Five other SNPs, on chromosomes 2 and 9, had lod scores >4.0 under the recessive model. Another 26 SNPs had lod scores >3.6 under either a dominant or recessive model. In addition, we are performing simulation studies to evaluate approaches toward subsetting the pedigree for optimal linkage analysis. Conclusions: Our linkage results suggest several novel non-APOE genetic effects, with the most compelling evidence on chromosomes 1, 2, 3, 6, and 9, for LOAD in the Amish. Computationally intensive multipoint linkage analysis is ongoing and will help further localize these signals.