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O1‐02‐01: Florbetaben for beta‐amyloid brain PET in Alzheimer's disease: Results of a multicenter phase 2 trial
Author(s) -
Sabri Osama,
Gertz Hermann-Josef,
Dresel Stefan,
Heuser Isabella,
Bartenstein Peter,
Bürger Katharina,
Hiemeyer Florian,
Reininger Cornelia,
Seibyl John,
Barthel Henryk
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.209
Subject(s) - medicine , grey matter , posterior cingulate , nuclear medicine , white matter , neuroscience , psychology , cortex (anatomy) , radiology , magnetic resonance imaging
movement or special nutrition (Mediterranean Diet) could be consider to be potential preventive strategies. A few studies support also the protective effects of cognitively stimulating activities like reading or playing chess. They seem to reduce the dementia risk by enhancing cognitive reserve. Methods: The AKTIVA-program was developed, implemented and evaluated to determine the effects of a cognitive intervention training, based on the concept of cognitively stimulating activities. It can be understood as a manual for a cognitively stimulating design in everyday life and represents an individual approach of prevention. Participants were informed about their individual possibilities of prevention and were systematically instructed and reinforced to increase cognitive stimulating activities as part of their daily routines. Initially the study consisted of 307 older persons (170 female, 72 6 7 years). The intervention was evaluated with a randomized, controlled pre-post-follow-up design. Participants were randomly assigned to 1 of 3 conditions: AKTIVA-intervention (N 1⁄4 126), AKTIVA-intervention plus nutritionand sport-guidance (N 1⁄4 84), no-intervention control-group (N 1⁄4 97). Outcome measures were among others cognitive function, assessment of memory-performance and participation in leisure activities. Results: Data of 208 persons were analyzed (dropouts N 1⁄4 67, exclusions N 1⁄4 32). Significant training effects were found for sub-assembly groups of the sample. Older Persons ( 75 years) showed enhanced speed of information processing (by Trail-Making-Test Version A) (F 1⁄4 4.17*, p < .05) and younger participants showed an improvement in subjective memory decline (by Memory Complaint Questionnaire) (F1⁄4 2.55*, p< .05). Furthermore, significant outcomes in leisure activities (reading, take a walk, meet friends) were found. Conclusions: Participation at the AKTIVA-intervention enhances activityfrequencies of leisure activities and has positive effects on outcome measures for sub-assembly groups. Further research is necessary to identify long-term intervention-benefits. Results of the one-year follow-up will be also presented at the congress.