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P3‐465: Oral treatment with the amyloid‐beta oligomer precipitating substance D3 improves pathology of Alzheimer's transgenic mice
Author(s) -
Willbold Dieter,
Groen Thomas,
Kadish Inga,
Bartnik Dirk,
Brener Oleksandr,
Nagel-Steger Luitgard,
Funke Susanne A.
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.2008
Subject(s) - in vivo , genetically modified mouse , in vitro , peptide , transgene , pathogenesis , amyloid (mycology) , pharmacology , chemistry , mechanism (biology) , biochemistry , microbiology and biotechnology , biology , medicine , pathology , gene , philosophy , epistemology
vs. 76.1+/8.8, p < 0.001) and had higher MMSE (20.8+/-8.0 vs. 19.4 +/6.9, p < 0.001). FTD patients used less dementia but more psychiatric medications. AD patients were 3.7 times more likely to use donepezil (53% vs. 27 %) and 1.7 times more likely to use memantine (42% vs. 35%) than FTD patients (p < 0.001, adjusted for age, onset age, MMSE, education, CDR Sum). FTD patients were 1.7 times more likely to use antipsychotics (10 vs. 5 %, p 1⁄4 0.013), 1.5 times more likely to use antidepressants (59 vs. 39%, p < 0.001) and 2 times more likely to use sedative/ anxiolytics (17 vs. 8%, p < 0.001) than AD. Neuropsychiatric symptoms were associated with medication use in FTD. Logistic regressions revealed FTD patients with higher elation (OR 1.4, p 1⁄4 0.025) or apathy scores (OR 1.3, p 1⁄4 0.027) were more likely to be on memantine, but less likely if had higher disinhibition scores (OR 0.765, p 1⁄4 0.037). Higher aberrant motor (OR 1.6, p 1⁄4 0.009) and appetite scores (OR 1.6, p 1⁄4 0.011) were associated with higher antipsychotic use, whereas higher depression (OR 0.482, p 1⁄4 0.016) and disinhibition (OR 0.635, p 1⁄4 0.025) were associated with less use. Antidepressant use was associated with higher agitation (OR 1.3, p 1⁄4 0.048) and depression (OR 1.6, p 1⁄4 0.003), but lower irritability scores (OR 0.76, p 1⁄4 0.040). Donepezil use wasn’t associated with any neuropsychiatric symptom. Conclusions: In this sample, psychiatric drug use is more common in FTD than AD but the reverse holds for dementia drugs. In FTD, neuropsychiatric symptoms were associated with psychiatric drug use but whether these were effects of or indications for use warrants further investigation.