Premium
P3‐445: Fitness for the aging brain study II: A multisite randomized controlled trial to determine the clinical benefits of physical activity for patients with mild‐to‐moderate Alzheimer's disease
Author(s) -
Cyarto Elizabeth V.,
Irish Muireann,
Cox Kay,
Almeida Osvaldo P.,
Flicker Leon,
Ames David,
Hill Keith,
Byrne Gerard J.,
Appadurai Kana,
Beer Christopher,
LoGiudice Dina,
Renehan Emma,
Waddell Fran,
Hughes Katherine,
Lautenschlager Nicola T.
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.1987
Subject(s) - randomized controlled trial , dementia , intervention (counseling) , observational study , quality of life (healthcare) , physical therapy , medicine , cognition , gerontology , caregiver burden , cognitive decline , activities of daily living , clinical trial , psychology , physical medicine and rehabilitation , disease , psychiatry , nursing
cognitive decline was precipitous to the point where floor effects precluded cognitive testing by 12 months. The safety and tolerability profile of the trial was favorable. Conclusions: 1) AOX supplementation to treat dementia in DS is ineffective at the dosages employed in the study; 2) Compliance utilizing the oral AOX supplementation was excellent; 3) The outcome measures utilized were highly sensitive to cognitive decline over the course of the study; and 4) Seizures associated with dementia in DS have a poor prognosis for cognitive functioning.