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P3‐394: Effect of electrical stimulation for dysphagia caused by vascular dementia
Author(s) -
Kim Sang-hyun,
Lee Jang-bok
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.1936
Subject(s) - medicine , dysphagia , swallowing , vascular dementia , hyoid bone , dementia , stimulation , anesthesia , surgery , disease
administered 5LOi to GP and observed no difference in brain Ab levels when compared to vehicle controls. Following administration of 5LOi to Tg4510 mice, there was a reduction in LTB4/CysLT, but no effect on gliosis, synaptic markers or p-tau/tau levels. Conclusions: Taken together, our results suggest that 3-week 5LOi treatment decreases brain Ab X-42 levels in amyloid models, without any effect on de novo generation of Ab and without a detectable reduction in LTB4/CysLT. The lack of LTB4/CysLT lowering in the amyloid models is a confound that may be due to localized effects surrounding the plaque. On the contrary, a significant decrease in LTB4/CysLT was observed following 5LOi administration to Tg4510 mice, without a significant effect on tau/synaptic markers suggesting that 5LOi may target only Ab-related pathology.