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P3‐369: Allopregnanolone promotes neurogenesis, restores cognitive function and reduces Alzheimer's pathology in adult triple transgenic Alzheimer's mice: Preclinical development and formulation
Author(s) -
Irwin Ronald W.,
Singh Chanpreet,
Liu Lifei,
Wang Junming,
Yao Jia,
Chen Shuhua,
Henry Sherry,
Thompson Richard F.,
Brinton Roberta D.
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.1911
Subject(s) - neurogenesis , dentate gyrus , hippocampus , allopregnanolone , hippocampal formation , genetically modified mouse , amyloid beta , neuroscience , endocrinology , medicine , subgranular zone , memory improvement , neural stem cell , psychology , pharmacology , chemistry , neuroactive steroid , transgene , cognition , subventricular zone , biology , stem cell , microbiology and biotechnology , receptor , disease , gabaa receptor , biochemistry , gene