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P3‐348: Effect of essential oil from Sohaphwangwon on the mouse Alzheimer model induced by beta‐amyloid
Author(s) -
Jeong Hajin,
Jeon Songhee,
Koo Byung-Soo
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.1849
Subject(s) - p38 mitogen activated protein kinases , neuroprotection , amyloid beta , hippocampus , viability assay , pharmacology , blot , chemistry , mapk/erk pathway , medicine , kinase , endocrinology , cell , biology , microbiology and biotechnology , biochemistry , disease , gene
receptors influences Tau phosphorylation probably by increasing calcium influx into neurons, which seems to rely on accumulation of new NR1/NR2B receptors in neuronal membranes and could involve the cyclin-dependent kinase 5 pathway. Conclusions: Collectively, our findings suggest that drugs acting as NMDA receptor antagonists could increase Ca2+ influx through inhibition of NR2A-containing receptors and enrichment of NR1/NR2B subunits. Such a change in receptor subunit composition could theoretically favour the appearance of adverse neuropathological effects, and should be evaluated further.