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P3‐251: Magnetic resonance biomarkers of neurodegeneration in a transgenic mouse model of Alzheimer's disease
Author(s) -
Marjanska Malgorzata,
Chamberlain R.,
Preboske G.,
Polk A.,
Kotilinek L.,
Wengenack T.M.,
Poduslo J.F.,
Youdas S.A.,
Ashe K.H.,
Garwood M.,
Jack C.R.
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.1751
Subject(s) - neurodegeneration , tauopathy , fractional anisotropy , genetically modified mouse , nuclear magnetic resonance , magnetic resonance imaging , nuclear medicine , pathology , diffusion mri , chemistry , neuroscience , transgene , medicine , biology , physics , disease , radiology , biochemistry , gene
Background: The histological abnormalities that characterize Alzheimer’s disease (AD) are commonly divided into four major classes: amyloid plaques, neurofibrillary tangles, inflammation, and neurodegeneration (NDG). In this work we compare the ability of various MR techniques (volume, T1r, T2r, ADC, FA) to detect the NDG in the rTg4510 mouse model (1) compared to wild-type (WT) mice. Methods: In vivo experiments were performed using a 9.4-T/31-cm horizontal bore magnet equipped with a Varian INOVA spectrometer. rTg4510 mice over express mutant human tau leading to an induced tauopathy and extensive neurodegeneration by 9 months of age. Four Tg4510 mice were imaged at 13 months of age and four WT mice were imaged at 12 months of age. All images were acquired using a quadrature surface coil. The volume image was acquired with a 3D multi-asymmetric spin-echo pulse sequence (2) with resolution 120 mm x 120 mm x 400 mm. The apparent diffusion coefficient (ADC) and fractional anisotropy (FA) and the rotating frame relaxation times, T1r and T2r, were measured with a 2D single slice with in-plane resolution of 80 mm x 80 mm, slice thickness of 1 mm. Results: All MR techniques detected the expected differences between WT and rTg4510 mice as shown in the table.