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P3‐237: Potential early diagnosis of Alzheimers disease using changes of the enteric nervous system
Author(s) -
Schäfer Karl H.,
Letiembre Maryse,
Semar Sandra,
Klotz Markus,
Liu Alex,
Fassbender Klaus,
Wyss-Coray Tony,
Schulz-Schaeffer Walter,
Van Ginneken Chris
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.1736
Subject(s) - enteric nervous system , myenteric plexus , nestin , central nervous system , pathology , biology , alzheimer's disease , nervous system , neuroscience , immunohistochemistry , medicine , disease , microbiology and biotechnology , stem cell , neural stem cell
of the disease. There is an unmet need for diagnostic biomarkers for FTD. The objective of this hypothesis generating study was to discover new candidate protein markers for early, differential diagnosis of FTD that may improve the performance of current diagnostic assays. Methods: Surface Enhanced Laser Desorption/Ionization (SELDI) TOF-MS and three different chromatographic surfaces were used to differentially profile proteins and peptides in CSF samples from 20 patients with FTD (age range 43-76 yrs) and 34 healthy controls (age range 42-86 yrs). Diagnosis was made using DSM-IV and ICD-10 criteria. Results: A total of 33 candidate biomarkers separating FTD from healthy aging were found with ROC values above 0.7 and p values below 0.01. Among them were fragments of the neurosecretory protein VGF as well as the neuroendochrine peptide Chromogranin B and a member of the complement system C3a. Conclusions: This novel panel of biomarkers could potentially be used to improve early diagnosis of FTD as well as to provide complementary information to help decision making in the development of disease modifying compounds.