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P3‐226: In vitro cellular uptake of a magnetic resonance imaging (MRI)/fluorescent contrast agent for detection of Cathepsin‐D activity in Alzheimer's disease
Author(s) -
Ta Robert M.,
Li Alex X.,
Suchy Mojmir,
Hudson Robert H.E.,
Pasternak Stephen H.,
Bartha Robert
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.1725
Subject(s) - dota , cathepsin d , chemistry , in vitro , mri contrast agent , cell culture , transfection , magnetic resonance imaging , microbiology and biotechnology , fluorescence , biochemistry , biology , gadolinium , enzyme , medicine , physics , radiology , quantum mechanics , gene , genetics , organic chemistry , chelation
correlated moderately with change in MMSE score. Conclusions: We conclude that WBA, VE and HV rates of change from our institute are not significantly different than those from the DRC and CIND, respectively. We also observed that the measured WBA, VE and HV rate changes were significantly higher in AD subjects relative to the normal control group, showing that our methods were sensitive enough to detect changes in subjects with AD.