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P3‐138: Moral judgment in Alzheimer's disease: A preliminary study
Author(s) -
Kim Eun-Jin,
Ha Ju-Won,
Kang Yeo-Jin,
Lim Se-Won,
Oh Kang-Seob
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.1635
Subject(s) - psychology , judgement , moral reasoning , depression (economics) , dementia , clinical psychology , cognition , disease , developmental psychology , psychiatry , social psychology , medicine , political science , law , economics , macroeconomics
difference between these two tests with respect to the ACE insertion/ deletion polymorphism. Chi-Square testing for trend was performed to evaluate the association ACE indel polymorphism with vascular cognitive decline; and logistic regression adjusting for the effects of age, education, gender, and ACE indel polymorphism to evaluate the factors influencing cognitive decline in post-lacunar infarct patients. Results: Among the 65 lacunar infarct patients, 23(35.4%) were women, the mean age was 64.46 6 12.35 years (26w88 years old). Twenty-two (33.8%) patients had senior high school education at least, but 10(15.4%) patients were illiterate. After ACE indel polymorphism analysis, 65 of our patients, 7(10.8%) were D/D genotype, 29(44.6%) were I/I genotype, and 29(44.6%) were I/D genotype. In our study, only fluency decline had trended to be not associated with D/D genotype (p 1⁄4 0.063) in Chi-square testing for trend. CASI (p 1⁄4 0.407) and MMSE (p1⁄4 0.997) did not show significant cognitive decline between these three genotype. After logistic regression analysis, we also did not found any significant difference between cognitive decline and ACE indel polymorphism in post-lacunar infarct patients. Conclusions: Our results can not revealed that ACE indel polymorphism is a predictor of cognitive decline in post-lacunar infarct patients. A partial explanation for this may be that the number of subjects in this study was small, and may not be able to validate the hypothesis estimate exactly. So, extent our study times to collect more patients and long term follow up our cases that may be a reasonable method to improve our results.