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P3‐088: Sleep disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women
Author(s) -
Yaffe Kristine
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.1582
Subject(s) - dementia , polysomnography , medicine , odds ratio , sleep apnea , cardiology , physical therapy , apnea , pediatrics , disease
SLEEP-DISORDERED BREATHING, A disorder characterized by recurrent arousals from sleep and intermittent hypoxemia, is common among older adults and affects up to 60% of elderly populations. A number of adverse health outcomes including hypertension, cardiovascular disease, and diabetes have been associated with sleep-disordered breathing. Cognitive impairment also has been linked to sleep-disordered breathing, but the majority of studies have been crosssectional or have relied on nonobjective measures of sleep-disordered breathing, thus limiting the ability to draw conclusions on the directionality of the association. It remains unclear whether sleep-disordered breathing precedes cognitive impairment in communitydwelling elderly individuals. Given the high prevalence and significant morbidity associated with both sleep-disordered breathing and cognitive impairment in older populations, establishing whether a prospective association exists between sleep-disordered breathing and cognition is important. This is especially important because ef-