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P3‐083: Leptin and dementia over 32 years in Sweden: The Prospective Population Study of Women
Author(s) -
Gustafson Deborah,
Bäckman Kristoffer,
Karlsson Cecilia,
Waern Margda,
Guo Xinxin,
Bengtsson Calle,
Skoog Ingmar
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.1577
Subject(s) - leptin , dementia , medicine , anthropometry , prospective cohort study , confounding , population , proportional hazards model , logistic regression , demography , rotterdam study , gerontology , endocrinology , obesity , disease , environmental health , sociology
Background: The 2009 World Alzheimer Report reported prevalence of dementia and Alzheimer’s disease worldwide, and highlighted the need for low and middle income countries, actually undergoing epidemiological transition, to quantify the burden of these age-related affections. There is still a particular dearth in epidemiological studies in Africa, where prevalence of dementia seems to be lower compared to high income countries. This study aimed at estimating the prevalence of dementia and assessing risk factors in elderly living in Central Africa: Bangui (Central African Republic) and Brazzaville (Republic of Congo). Methods: Two population-based studies were carried out in districts of Bangui and Brazzaville during 2008 and 2009. Elderly aged over 65 years were recruited by a door-to-door approach. They were interviewed about socio-demographical data, medical history, psychosocial factors and depressive symptoms. The Community Screening Interview for Dementia tests were conducted. Subjects who had a poor performance (<25.5/30) at the cognitive section of the CSI-D or had less than ten at the Five-Word Test were clinically assessed by a neurologist. Further psychometrical tests were conducted as Free and Cued Selective Reminding Test, Isaacs Set Test, Zazzo’s cancellation test. The DSM-IV and NINCDS-ADRDA criteria were required for dementia and Alzheimer’s disease diagnoses. Results: Among the 496 individuals interviewed in Bangui, 188 subjects were suspected of dementia, 165 (32.9%) were re-examined by a neurologist. Forty were identified with dementia (including 7 vascular dementia) and 1 was unclassifiable. In Brazzaville, among the 520 interviewed elderly, 148 (28.5%) were suspected of dementia and 133 of them were clinically assessed by a neurologist. After neurological assessment, 35 were identified with dementia (including 11 vascular dementia). Prevalence of dementia was 8.1% (95%CI [5.8-10.8]) in Bangui and 6.7% (95%CI [4.7-9.2]) in Brazzaville. Absence of schooling was associated to cognitive impairment in both cities. Factors associated to dementia in Bangui and Brazzaville were determined. Conclusions: Prevalence of dementia in these cities is higher than the ones previously observed in West Africa and similar to the ones of high income countries. Epidemiological transition, growing prevalence of cardio-vascular disease risk factors and traumatic life events occurred in these cities could be involved.