Premium
P3‐061: The contribution of type 2 diabetes to the burden of Alzheimer's disease
Author(s) -
Mucha Lisa,
McLaughlin Trent,
Song Rui,
Sklar Ami
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.1555
Subject(s) - medicine , confidence interval , type 2 diabetes , medical prescription , disease , pharmacy , diabetes mellitus , incidence (geometry) , alzheimer's disease , pediatrics , endocrinology , pharmacology , physics , family medicine , optics
Common and internal carotid artery atherosclerosis and intima-media thickness (IMT) were measured quantitatively and compared between groups. Demographics and cardiovascular risk factors were also evaluated. Results: Regarding carotid artery atherosclerosis, individuals with obstruction>70% in the left internal carotid artery (LICA) had 3.7 times higher risk for AD than those that had obstruction<70% (OR 1⁄4 3.68, CI 95% 1.42-9.58, p 1⁄4 0.005) and a 4.4 times higher risk for VaD (OR 1⁄4 4.35, CI 95% 1⁄4 1.70-11.10, p 1⁄4 0.001) on univariate analysis. After adjusting for age, gender and years of education, LICA continued to be associated with AD and VaD (AD: OR 1⁄4 4.00, CI 95% 1.35-11.87, p 1⁄4 0.01; VaD: OR 1⁄4 4.39, CI 95% 1.50-12.83, p 1⁄4 0,007). On univariate analysis, critical obstruction in the right internal carotid artery (RICA) was associated with VaD (OR 1⁄4 2.73, CI 95% 1.05-7.11, p 1⁄4 0.03), but not with AD (p 1⁄4 0.76). However, after multivariate analysis (considering age, gender and years of education), the association between VaD and RICA atherosclerosis lost significance (OR 1⁄4 2.58, CI 95% 0.91-7.30, p 1⁄4 0.08). In order to verify if the association of LICA atherosclerosis with AD and VaD was due to cerebral infarction, data was adjusted for the presence of infarction, confirmed by neuropathological examination. After adjustment, only AD remained associated with LICA atherosclerosis (p 1⁄4 0.01 for AD and p 1⁄4 0.06 for VaD). Groups were similar in terms of common carotid artery atherosclerosis and IMT. Conclusions: Severe carotid artery atherosclerosis, particularly in LICA, was associated with AD and VaD. The association with AD appeared to be independent of cerebral infarction, highlighting the importance of cerebral hypoperfusion in this disease.