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P3‐060: Carotid artery atherosclerosis is associated with Alzheimer disease and vascular dementia: A postmortem study
Author(s) -
Suemoto Claudia K.,
Grinberg Lea T.,
Ferretti Renata E.L.,
Menezes Paulo R.,
Farfel José M.,
Leite Renata E.P.,
Oliveira Kátia C.,
Tampellini Edilaine,
Jacob-Filho Wilson,
Nitrini Ricardo,
Pasqualucci Carlos A.
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.1554
Subject(s) - medicine , univariate analysis , vascular dementia , dementia , cardiology , autopsy , internal carotid artery , common carotid artery , carotid artery disease , vascular disease , pathology , disease , carotid arteries , multivariate analysis , carotid endarterectomy
estimate the prevalence of dementia and its clinical subtypes among northerners aged 55 years or older and to examine associations with age, gender, and laboratory test. Methods: A simple cross-sectional descriptive study was carried out in Medicine department, Ahmadu Bello university teaching hospital, Zaria, Kaduna Nigeria. Of 147 people screened with a vernacular adaptation of the Mini-Mental State Examination (MMSE), all those scoring at or below the cut-off of 23 were further evaluated. Diagnostic laboratory test investigations were employed to analyze serum samples tested for HIV antibodies using two sequential rapid HIV tests and one ELISA confirmatory test kit as recommended by the Nigerian Federal Ministry of Health series algorithm for rapid HIV testing. Results: A total of 147 patients were screened with the vernacular adaptation of MMSE comprising of 82% male and 18 female with a mean age of 62.2 6 4.4. The prevalence of dementia was 34.1%.The condition was early(mild) in 24.5%, middle(moderate) in 68%, and late(severe) in 7.5%.Of the subjects with dementia, 32% had vascular dementia, 1.4% had AIDS-related dementia, and 0.7% had senile dementia. Age and low education was significantly associated with dementia. Conclusions: The prevalence of dementia among study group was high and dementia is an important health problem of the elderly population with intellectual disability. Age and low education are strongly associated with dementia. Identification of risk factors points towards the possibility of prevention