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P3‐032: Association among depression, apolipoprotein E4 allele, mild cognitive impairment and conversion to dementia in a Japanese community
Author(s) -
Nose Mayumi,
Kodama Chiine,
Ikejima Chiaki,
Yasuno Fumihiko,
Mizukami Katsuyoshi,
Asada Takashi
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.1525
Subject(s) - dementia , depression (economics) , psychology , mood , risk factor , psychiatry , major depressive episode , clinical psychology , medicine , disease , economics , macroeconomics
Background: The metabolic syndrome is reported to have detrimental effects on cognition. However, this association may depend upon sex and age and may be modulated by inflammation in distinct populations. Therefore, we investigated the association between metabolic syndrome and cognitive functioning in a population of middle-aged and older men and the impact of inflammatory responses. Methods: This community-based, cross-sectional study included 3,369 men aged 40-79 years from eight centres enrolled in the European Male Ageing Study (EMAS). Cognitive function was assessed using the Rey-Osterrieth Complex Figure (ROCF) test, the Camden Topographical Recognition Memory (CTRM) test and the Digit Symbol Substitution Test (DSST). Metabolic syndrome was defined by the National Cholesterol Education Program’s ATP-III criteria. Serum high sensitivity C-reactive protein (hs-CRP) levels were determined by solid-phase, chemiluminescent immunoassay. Associations between cognitive performance and metabolic syndrome and the influence of hs-CRP were explored using linear regression models. Results: Complete cognitive and metabolic syndrome data from 3152 subjects were included in the analysis, of which 1007 (32%) fulfilled the criteria for metabolic syndrome. There was no significant associations between cognitive scores and metabolic syndrome after adjustment for putative health and lifestyle confounders. However, analysis of the individual factors revealed an inverse association between glucose levels and cognition. Hs-CRP levels did not modulate cognitive performance. Conclusions: We found no independent associations between the presence of the metabolic syndrome and cognitive function in a representative sample of community-dwelling, middle-aged and older European men. Hs-CRP levels were not associated with cognitive performance either, regardless of the presence or absence of the metabolic syndrome. Of the individual components of the metabolic syndrome, only hyperglycaemia was associated with poorer cognitive performance. These findings suggest that a dysregulated carbohydrate metabolism is associated with lower cognitive function but the nature of this relationship requires further investigation.