Premium
P3‐010: Is there an increased risk of death from natural causes in young adult apolipoprotein E epsilon 4 carriers?
Author(s) -
Yaari Roy,
Langbaum Jessica B.,
Corneveaux Jason J.,
Huentelman Matthew J.,
Beach Thomas G.,
Valla Jon,
Roher Alex E.,
Reiman Eric M.
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.1503
Subject(s) - apolipoprotein e , cohort , medicine , odds ratio , logistic regression , disease , cohort study
Background: Some early life factors have been demonstrated to be associated with risk for dementia. The aim of the present study was to examine the association of midlife report of crisis following parental death at different age groups with dementia many years later. Methods: In 1963, 3749 participants of the IIHD study were asked whether they have experienced crisis following parental (paternal or maternal) death during the following ages: 0-6. 7-12. 13-18 or >18 years. Dementia was assessed over three decades later in 1,652 participants among 2,604 survivors of the original cohort. Results: Controlling for age, in a logistic regression, the odds for dementia relative to individuals who reported crisis following paternal death at the age of 18 and above, were 3.03 (95%CI 1.42-6.61), 2.15 (95% CI 0.875.31) and 2.36 (95%CI 1.05-5.28) for those who reported crisis following paternal death at the ages of 0-6, 7-12 and 13-18. Controlling for age, in a logistic regression, the odds for dementia relative to individuals who reported crisis following maternal death at the age of 18 and above were 3.36 (95% CI 1.25-9.01), 3.96 (95% CI 1.38-11.33) and 2.65 (95% CI 0.99-7.08) for those who reported crisis following maternal death at the ages of 0-6, 7-12 and 13-18. Odds for dementia were 0.60 (95% CI 0.32-1.11) and 0.52 (95% CI 0.24-1.15) for participants who reported paternal or maternal death respectively, at ages of 18 and above compared to participants who did not report such a crisis Conclusions: crisis following parental death during childhood is associated with increased risk for dementia. Future studies should assess possible mechanisms and potentials for intervention and modification