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P2‐437: Neuropychological correlates of brain atrophy shown on voxel‐based morphometry in Alzheimer's disease
Author(s) -
Kanetaka Hidekazu
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.1490
Subject(s) - voxel , statistical parametric mapping , neuropsychology , atrophy , voxel based morphometry , dementia , nuclear medicine , psychology , wechsler adult intelligence scale , audiology , parahippocampal gyrus , medicine , temporal lobe , cognition , radiology , magnetic resonance imaging , psychiatry , disease , white matter , epilepsy
(Figure C). However, there was substantial overlap in the regions affected in each subgroup. Furthermore, although the classification (SVM) analysis produced a 100% separation between controls and all PCA patients, there was no clear separation between the three putative subgroups (Figure D). Conclusions: PCA is characterised by marked thinning of posterior cortices with considerable heterogeneity which corresponded to the predominant deficit. However, there were no clearly distinct subgroups. Phenotypic variation in PCA is most appropriately conceptualised as different points within a space of continuous variation rather than discrete, well-defined syndromes.