Premium
P2‐429: Gender differences in the relationship between Aβ burden and memory
Author(s) -
Pike Kerryn E.,
Ellis Kathryn A.,
Villemagne Victor L.,
Ames David,
Good Norm,
Martins Ralph M.,
Szoeke Cassandra,
Masters Colin L.,
Rowe Christopher C.
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.1482
Subject(s) - episodic memory , pittsburgh compound b , cognition , psychology , effects of sleep deprivation on cognitive performance , audiology , posterior cingulate , semantic memory , executive functions , clinical psychology , medicine , cognitive impairment , neuroscience
mild cognitive impairment (aMCI) and 18 age-matched control (CN) subjects participated in this study and completed the neuropsychological test. The intrinsic amygdala functional connectivity (AFC) network activity, measured with m values, which are Fisher-transformed cross-correlation coefficients, was correlated to Geriatric Depression Scale (GDS) and Rey Auditory Verbal Learning Test delayed recall (RAVLT-DR) scores. Results: aMCI subjects had significantly higher GDS scores, worse RAVLT-DR scores (p < 0.01), and markedly enhanced AFC network activity in the prefrontal, parietal and temporal lobules, and subcortical regions. The AFC network activity was positively correlated with the GDS in the left inferior parietal cortex (IPC), fusiform (FFG), inferior temporal cortex (ITC), right IPC, dorsolateral prefrontal cortex (DLPFC), insula (Ins), thalamus (Tha) and parahippocampus (PHG) in the aMCI group, but only in the left IPC in the CN group; whereas it was positively correlated with RAVLT-DR scores in the left posterior cingulated cortex (PCC) and precuneus (Pre) in both groups, but only negatively correlated in the right postcentral gyrus, inferior frontal gyrus, DLPFC and IPC in the CN group. Conclusions: Growing evidence also has confirmed that there is a certain relationship between depression and memory loss [2]. Moreover, late-life depression is considered a preclinical stage of dementia [3]. Presently, the significant different correlation patterns in the above distinct nodes within the AFC network were identified. This finding suggests that the AFC network has dual effects that link depressive symptoms and memory deficits. The altered neural substrates of the AFC network underlying the emotional and cognitive functions mediation were associated with disease state. Reference: 1. Luiz Pessoa. Nat. Rev. Neurosci.2008, 9, 143-148. 2. Ganguli M, et al. Arch Gen Psychiatry. 2006;63(2):153-160. 3. Steffens DC et al., Arch Gen Psychiatry. 2006;63(2):130-8.