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P2‐415: Early stage of Alzheimer's disease: Transient oscillations and neural dynamics as predictive markers of the pathology
Author(s) -
Vialatte Francois B.,
Sole-Casals Jordi,
Hazart Aurelien,
Prvulovic David,
Dauwels Justin,
Pantel Johannes,
Haenschel Corinna,
Cichocki Andrzej
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.1468
Subject(s) - electroencephalography , neuroscience , cognition , psychology , disease , perception , dynamics (music) , cognitive psychology , medicine , pathology , pedagogy
groups, response times for incongruent answers were shorter than those for congruent answers (F(1,34) 1⁄4 15.8, p < .0005). There were no differences between self/other in response times and discrepancy (Fs(2,34)<1, n.s.). The fMRI analysis performed on the group of 20 controls showed similar activations during ‘‘self’’ and ‘‘other’’ conditions versus baseline. These included medial-prefrontal cortex bilaterally, posterior hippocampus bilaterally, left striatum, left lateral prefrontal cortex, left medial temporal gyrus, and visual posterior regions. Conclusions: The self-appraisal task is a novel and promising fMRI paradigm that can be used to explore the neuro-anatomical correlates of anosognosia. Further results from the comparison between ADs, MCIs and controls will be presented and discussed.