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P2‐412: Individual differences in white matter integrity contribute to adult age differences in executive functioning
Author(s) -
Burgmans Saartje,
Gronenschild Ed,
Boxtel Martin,
Vuurman Eric,
Uylings Harry,
Jolles Jelle,
Raz Naftali
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.1465
Subject(s) - white matter , splenium , corpus callosum , fractional anisotropy , psychology , diffusion mri , hyperintensity , structural integrity , neuroscience , medicine , magnetic resonance imaging , radiology , structural engineering , engineering
Subregional analysis revealed less loss of tissue in CC1 in improvers vs. non-improvers (p < 0,01) and vs. decliners (p < 0.01) whereas it was greater in decliners vs non-decliners (p 1⁄4 0,05) and CC5 in improvers vs non-improvers (p < 0,05) and vs decliners (p < 0,05), although the three latter results was not significant after Bonferroni-correction (p < 0,01) for repeated measures. Results did not change when including patients with dementia. Conclusions: The presented results indicate an association between longitudinal measures of CC tissue loss and subjective memory complaints. Anterior areas may be particularly important, pointing towards involvement of frontal circuitry.