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P2‐407: Encoding reinforcement improves memory in older adults: Evidence from a high‐field functional MRI study
Author(s) -
Song Xiaowei,
D'Arcy Ryan C.N.,
Fisk John D.,
Major Alma,
Beyea Steven,
Rockwood Kenneth
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.1460
Subject(s) - episodic memory , encoding (memory) , functional magnetic resonance imaging , stimulus (psychology) , psychology , perception , cognition , semantic memory , repetition (rhetorical device) , visual memory , audiology , cognitive psychology , neuroscience , medicine , linguistics , philosophy
Interestingly, these APP-positive deposits were thought to be derived from cholinergic nerve terminals since they were also positive with choline acetyltransferase and synaptophysin. These phenomena are thought to be due to disburbances of unfolded protein responses (UPR) and protein aggreagation since these were also stained with phosphorylated PERK, an UPR marker, and g-tubulin, an aggresome marker, and cathepsin-D, a lysosomal marker. Conclusions: Thus, aging-associated disturbances of UPR and accumulation of protein aggregates at cholinergic nerve terminals in specific areas of brain regions related with memory could be associated with normal decline of memory in aged people. In addition, these age-related changes might be the most vulnerable factors to pathologic insults to result in neurodegenerative conditions, such as AD.