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P2‐388: Quantitative comparison of 3T and 1.5T MRI in the evaluation of cortical thickness and subcortical volume using FreeSurfer
Author(s) -
Kim Byeong Chae,
Park Sang-Joon,
Choi Seong Min,
Yoon Woong,
Seo Sang Won,
Na Duk L.
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.1440
Subject(s) - magnetic resonance imaging , nuclear medicine , brain size , medicine , sagittal plane , segmentation , cortex (anatomy) , anatomy , psychology , radiology , neuroscience , computer science , artificial intelligence
autoradiography of postmortem AD brains. Binding affinity of test compounds to PHF-tau was examined by in vitro binding assay. Blood-brain barrier permeability was assessed by intravenous administration of test compounds to mice. Results: Microscopic observation demonstrated that both Cpd.B and C stained neurofibrillary tangles intensely and stained senile plaques faintly in AD brain sections. Autoradiographic study of AD brain sections additionally demonstrated selective binding ability of a tracer dose of F-labeled Cpd.B and C to neurofibrillary tangles. In vitro binding assay indicated the high binding affinity of these compounds to PHF-tau. Furthermore, biodistribution study of [F]Cpd.C in mice exhibited excellent brain uptake (6.0 % injected dose/g at 2 min post injection) and rapid clearance (1.3 % injected dose/g at 2 min post injection) from normal brain tissue. The optimization of the pharmacokinetic properties of these compounds is now in progress. Conclusions: These findings suggest that [F]Cpd.C is a potential candidate as a PET tracer for imaging tau pathology in AD patients.