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P2‐386: Comparison of functional parameter between 18 F‐FDG and 11 C‐PIB PET for dual assessment
Author(s) -
Kim Su Jin,
Kim Yu Kyeong,
Lee Jae Sung,
Yoon Eun Jin,
Kim Sang Eun,
Lee Dong Soo
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.1438
Subject(s) - nuclear medicine , voxel , positron emission tomography , standardized uptake value , perfusion , medicine , cerebral blood flow , radiology
autoradiography of postmortem AD brains. Binding affinity of test compounds to PHF-tau was examined by in vitro binding assay. Blood-brain barrier permeability was assessed by intravenous administration of test compounds to mice. Results: Microscopic observation demonstrated that both Cpd.B and C stained neurofibrillary tangles intensely and stained senile plaques faintly in AD brain sections. Autoradiographic study of AD brain sections additionally demonstrated selective binding ability of a tracer dose of F-labeled Cpd.B and C to neurofibrillary tangles. In vitro binding assay indicated the high binding affinity of these compounds to PHF-tau. Furthermore, biodistribution study of [F]Cpd.C in mice exhibited excellent brain uptake (6.0 % injected dose/g at 2 min post injection) and rapid clearance (1.3 % injected dose/g at 2 min post injection) from normal brain tissue. The optimization of the pharmacokinetic properties of these compounds is now in progress. Conclusions: These findings suggest that [F]Cpd.C is a potential candidate as a PET tracer for imaging tau pathology in AD patients.