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P2‐376: Dissociated gray matter atrophy and hypoperfusion in Alzheimer's disease and Parkinson's disease
Author(s) -
Zhang Yu,
Tosun Duygu,
Mojabi Pouria,
Nezamzadeh Marzieh,
Zhan Wang,
Shirley Cheryl,
Kang Gail,
Glass Graham,
Marks William,
Weiner Michael W.,
Schuff Norbert
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.1428
Subject(s) - atrophy , voxel based morphometry , white matter , perfusion , grey matter , medicine , statistical parametric mapping , pathology , magnetic resonance imaging , cardiology , psychology , neuroscience , radiology
et al). MRI scans at 3 year follow-up were compared between groups. The CC was semi-automatically outlined on MRI images and quantified at baseline and follow-up. ARWMCs were visually scored using Fazekas scale (mild, moderate, severe) at baseline. Total CC area at follow-up was entered into ANCOVA analysis to test for differences between groups (AD, SD, non-demented). Subregional differences were analysed using repeatedmeasures ANCOVA, and significant results were further examined using univariate analysis. Results: Groups differed with regards to age, ARWMC-load and gender. Therefore the variables were entered into the ANCOVA analysis as covariates. AD, SD and non-demented elderly subjects did not differ in total CC area. AD and SD patients had smaller CC1 and CC5 compared to non-demented elderly subjects at 3 year follow-up, but did not differ in other CC subregions. No difference in subregional areas between the 2 patient groups. Conclusions: The presented results indicate that anterior and posterior CC atrophy is associated with dementia. No specific atrophy pattern was identified in dementia subtypes, although this may have been due to the relatively small number of subjects who developed dementia.