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P2‐364: Can you distinguish SVD from Alzheimer's with CVD by using MRI and neuropsychological findings?
Author(s) -
Shim Yong Soo
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.1416
Subject(s) - vascular dementia , dementia , neuropsychology , clinical dementia rating , atrophy , cardiology , psychology , mini–mental state examination , magnetic resonance imaging , medicine , disease , audiology , cognition , neuroscience , radiology
neuroimaging characteristics of aMCI patients with PD (aMCI-PD) and without PD (aMCI-PD) to explore the different neural basis for cognitive dysfunction in two groups. Methods: We used voxel-based morphometry using a 3-T MRI scanner to compare gray matter volume between 88 patients with aMCI-PD and 41 those with aMCI-PD as well as neuropsychologic profiles using the Seoul Neuropsychological Screening Battery. Results: No significant differences in age, gender, education level, duration of memory complaints, K-MMSE, CDR, and SOB were found between patients with aMCI-PD and aMCI-PD. On comparison the detailed neuropsychological test, patients with aMCI-PD showed more severe cognitive deficits in delayed recall of verbal memory (p1⁄4 0.03) and visual recognition (0.01). Compared to controls, patients with aMCI-PD showed significantly decreased GM density in the bilateral temporal and posterior cingular areas. However, patients with aMCI-PD showed significantly decreased GM density in the anterior and posterior cingulate areas relative to controls. On a direct comparison between groups, aMCI-PD showed decreased GM density in the bilateral temporal, bilateral prefrontal, and right parietal areas relative to aMCI-PD, whereas decreased GM density in aMCI-PD relative to aMCI-PD was localized in the posterior cingulate areas as well as in the bilateral parietal areas. Conclusions: Our data suggest that different neural basis for aMCI between aMCI-PD and aMCI-PD would exist.