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P2‐321: The potential effect of PSA‐NCAM expression level on the spatial memory impairments in Tg2576 and Wort+GFX injecting Alzheimer models
Author(s) -
Guo Ziyuan,
Liu Dan,
Wang Xiong,
Wang Jianzhi,
Zhu Lingqiang
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.1372
Subject(s) - morris water navigation task , hippocampus , hippocampal formation , neural cell adhesion molecule , immunohistochemistry , neuroscience , western blot , memory impairment , water maze , polysialic acid , synaptic plasticity , immunofluorescence , psychology , endocrinology , medicine , chemistry , antibody , immunology , cognition , receptor , biochemistry , cell adhesion , gene , cell
levels of CaN and pCREB in their hippocampus. Results: We found that CaN was increased and pCREB was significantly reduced in the hippocampus and cortex of AD patients and, to a lesser extent in MCI subjects as compared to non-demented individuals. Indeed there was a significant inverse correlation between pCREB levels and MMSE scores among AD patients, MCI subjects and normal individuals. Furthermore, icv injection of Ab oligomers that results in memory dysfunction in mice increased CaN and decreased pCREB, establishing a causal link between Ab-driven cognitive deficits and CaN hyper-activation. Conclusions: Collectively these results reveal that increased CaN activity may be central to Ab oligomer-induced memory deficits in AD and suggest it as a potential pharmacological target.