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P2‐305: Analysis of N‐cadherin interacting proteins in Alzheimer's diesase
Author(s) -
Ando Koichi,
Maesako Masato,
Asada Megumi,
Kubota Masakazu,
Aoyagi Nobuhisa,
Kuzuya Akira,
Uemura Kengo,
Kawamata Jun,
Takahashi Ryosuke,
Kinoshita Ayae
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.1356
Subject(s) - cadherin , mapk/erk pathway , immunoprecipitation , microbiology and biotechnology , presenilin , western blot , signal transduction , hek 293 cells , biology , alzheimer's disease , tau protein , chemistry , cell culture , cell , biochemistry , gene , medicine , disease , genetics
and 3 6 0.25 year old) were used in this study. Animals were randomly assigned to 2 groups as follows: Group 1 (n1⁄4 6), normal chow and group 2 (n 1⁄4 6), chow supplemented with 2% cholesterol . Cholesterol-treated animals and their matched controls were euthanized 12 weeks later. Results: Cholesterol-enrichded diets inhibit active Akt and m-TOR. Inhibition of Akt is associated with increased levels of GSK3ab, an enzyme that increases bamyloid and phosphorylated tau production. Inhibition of mTOR also causes tau hyperphosphorylation. Conclusions: Our results suggest that cholesterol-enriched diets cause AD-like pathology by mechanisms involving an Akt/mTOR signaling pathway.