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P2‐258: Beta‐amyloid induces neuronal death through disrupting polyamine homeostasis
Author(s) -
Lin Chih-Li,
Liu Guang-Yaw,
Hung Hui-Chih
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.1308
Subject(s) - ornithine decarboxylase , neurotoxicity , ornithine decarboxylase antizyme , polyamine , downregulation and upregulation , intracellular , microbiology and biotechnology , biochemistry , biology , chemistry , toxicity , enzyme , organic chemistry , gene
regulates mdh2 at post-transcriptional level. H2O2 reduced miR-378 level by 14%. In contrast, H2O2 increased mdh2 mRNA level by 22%. Thus, the up-regulation of mdh2 by H2O2 is consistent with the reduced miR378 expression. Conclusions: The diverse altered mRNA levels of these genes are consistent with the changes in the activities of KGDHC, SDH and MDH in AD brains. The results suggest that oxidantinduced gene regulation may occur at both transcriptional and post-transcriptional levels. Thus, identification of transcription factors or microRNAs that regulate metabolic genes will likely be important in understanding the pathophysiology of AD and in the development of new therapeutic strategies.