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IC‐P‐112: MRI of Histological Tissue: Effect of Passive Gadolinium‐Staining
Author(s) -
Hoang Dung Minh,
Boutajangout Allal,
Bertrand Anne,
Pun Susan,
Fakri-Bouchet Latifa,
Sigurdsson Einar,
Wisniewski Thomas,
Wadghiri Youssef Zaim
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.127
Subject(s) - staining , histology , gadolinium , congo red , chemistry , contrast (vision) , nuclear medicine , magnetic resonance imaging , pathology , hepes , nuclear magnetic resonance , medicine , radiology , physics , optics , organic chemistry , biochemistry , adsorption
across groups. However, when the proportion of 1.5T and 3T scans differed across patient groups the segmentation biases were apparent (Figure 1A & B, highlighted in green) and reduced the reliability of the results. These biases reduced as the proportion of 1.5T and 3T images in each patient group gets closer to the situation where they are matched across patient groups. Including field strength as a covariate reduced the biases but also reduced the amount of significant results. Conclusions: This study shows that field strength influences VBM assessments of atrophy: combining data acquired at 1.5T and 3T in VBM studies is however possible as long as the proportion of different field strengths is matched across patient groups.