Premium
P2‐208: Neuroprotective effect of a blood brain permeable triazine derivative through inhibition of NF‐κB and HSP‐90 along with activation of Nrf2 signaling
Author(s) -
Khodagholi Fariba,
Ansari Niloufar,
Tusi Solaleh Khoramian,
Amini Mohsen,
Amirabad Azim Dehghan
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.1257
Subject(s) - neuroprotection , oxidative stress , pharmacology , glutathione , chemistry , reactive oxygen species , antioxidant , caspase 3 , biochemistry , apoptosis , biology , enzyme , programmed cell death
by increased caspase activity and accordingly, not affected by z-VAD-fmk. Instead, the PARP-1 inhibitor 3-ABA almost completely prevented H2O2 induced-death by reducing both apoptosis and necrosis, in elderly as well as young individuals. Conclusions: H2O2-induced death of human lymphocytes displays both apoptotic and necrotic features, is highly PARP-1-dependent but independent of caspase activation. Aging is associated with an increase in apoptotic death. Understanding the mechanisms of cell death might have implications for the study of neurodegenerative and proliferative disorders.