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IC‐P‐105: 1 H MR Spectroscopy in Presymptomatic MAPT mutation carriers: A Biomarker for Tau Mediated Pathology
Author(s) -
Kantarci Kejal,
Boeve Bradley F.,
Wszolek Zbigniew K.,
Rademakers Rosa,
Whitwell Jennifer L.,
Baker Matt C.,
Senjem Matthew L.,
Knopman David S.,
Petersen Ronald C.,
Jack Clifford R.
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.120
Subject(s) - medicine , pathology , tau protein , biomarker , precuneus , creatine , pathogenesis , atrophy , pathological , alzheimer's disease , gastroenterology , disease , biology , genetics , psychiatry , cognition
head coil. A T1 weighted anatomical scan (MPRAGE) guided voxel placement. Short echo acquisitions (PRESS sequence; TR1⁄4 2000 ms; TE1⁄4 32 ms; number of averages 1⁄4 64) were collected from two 1.5x2.5x1.5 cm voxels: 1) in the left MTL centered on the hippocampus, and 2) a control voxel in the left occipital wall. Data analysis: Spectra were fitted and quantified using LC Model. Metabolites were calculated as absolute concentrations (millimolar) scaled to the unsuppressed water peak. Voxels were segmented into three tissue types to correct for partial volume effects. Pearson’s coefficients (adjusting for age) were calculated for SPPB and GV in relation to MTL metabolite absolute concentrations (N-acetyl aspartate, choline, creatine and myoinositol). Independent t-tests (95% CI) examined mean differences in MTL metabolite concentrations in high versus low 400-MW and TUG performance. Results: Pearson coefficients were statistically significant for correlations between SPPB and MTL metabolites, choline (r 1⁄4 -.930, p < .001), creatine (r 1⁄4 -.674, p 1⁄4 .023), and myoinositol (r 1⁄4 -.606, p 1⁄4 .048). GV was also negatively correlated with MTL choline (r 1⁄4 -.600, p 1⁄4 .051) and myoinositol (r 1⁄4 -.617, p 1⁄4 .043). Correlations remained significant after accounting for age. No significant correlations existed between physical function and control voxel metabolites. 400-MW performance revealed significant differences in MTL choline (p 1⁄4 .043, mean diff 1⁄4 -0.426; 95% CI -.834 to -.0172). Conclusions: Impaired physical function is associated with MTL neurodegenerative processes in older adults with MCI, independent of age.