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P2‐141: Apathy but not other affective symptoms is predicting conversion to dementia in mild cognitive impairment
Author(s) -
Sobow Tomasz,
Magierski Radoslaw,
Flirski Marcin,
Wojtera Marcin,
Kloszewska Iwona
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.1188
Subject(s) - apathy , dementia , irritability , depression (economics) , anxiety , psychiatry , psychology , prospective cohort study , clinical psychology , medicine , cognition , disease , economics , macroeconomics
measure ANOVA revealed significant main effects of personality (F(4, 592) 1⁄4 297.76, p < .001) and time (F(2, 296) 1⁄4 3.25, p < .05), and significant interactions of time and personality (F(8, 1184)1⁄4 2.41, p1⁄4 .01), and of personality and diagnosis (F(4, 592) 1⁄4 5.48, p < .001) as well as of personality and sex (F(4, 592)1⁄4 5.08, p< .001), but there was no significant interaction between personality, diagnosis and sex. MCI subjects scored significant higher on neuroticism and lower on openness. Conclusions: The results support the hypothesis that MCI subjects differ in their personality traits relative to healthy controls. Premorbid high neuroticism is a possible risk factor for developing MCI.