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IC‐P‐101: Longitudinal Regional Cerebral Blood Flow Change Due to Normal Aging: A Community‐Based Study
Author(s) -
Nemoto Kiyotaka,
Yamashita Fumio,
Kodama Chiine,
Tamura Masashi,
Matsuda Hiroshi,
Mizukami Katsuyoshi,
Asada Takashi
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.116
Subject(s) - grey matter , cerebral blood flow , white matter , nuclear medicine , partial volume , perfusion , medicine , single photon emission computed tomography , cerebral perfusion pressure , cardiology , magnetic resonance imaging , radiology
Background: Although there are several studies which explore the aging effect on regional cerebral blood flow (rCBF) using single-photon emission computed tomography (SPECT), most of studies are cross-sectional study and they have not considered the partial volume effect. Partial volume effect correction (PVC) is necessary to evaluate the rCBF accurately. In this study, we evaluated the longitudinal rCBF change due to normal aging with and without PVC. Methods: Subject are 78 healthy cognitively normal subjects (34 males and 44 females, mean(SD): 72(4.3)). Their average MMSE score was 28.4 at baseline. With the hypothesis that different age range of the subjects might show different rate in volume reduction or cerebral perfusion, the subjects were divided into three groups (under 69, 70-74, and over 75 years old). All of the subjects underwent three-dimensional T1 weighted MRI and Tc-99m ECD SPECT twice, at baseline and 3-years follow-up. MR images were segmented into grey matter, white matter, and cerebral-spinal fluid using SPM5. Using the grey matter and white matter images, partial volume correction was performed on the SPECT images. Paired t-tests were performed on the grey matter images, the SPECT images with PVC, and the SPECT images without PVC to evaluate the aging effect on rCBF and how PVC will affect the result. Results: Subjects under 69 years old showed cortical volume reduction due to aging in prefrontal, orbital frontal, cingulate, medial temporal regions, and parietal lobules. The analysis with nonPVC SPECT revealed the similar reduced perfusion regions as cortical volume reduction. On the other hand, the analysis with PVC SPECT confined the reduced perfusion regions to the posterior cingulate and orbital frontal gyrus. Subjects over 70 years old did not show any significant volume or perfusion reduction due to normal aging. Conclusions: Our results suggest that normal aging cause the perfusion reduction in the limited regions, and posterior cingulate cortex is susceptible to the even normal aging effect. It is also speculated that the cortical reduction or cerebral perfusion reduction rate might get slower in the cognitively intact subjects over 70 years old.