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IC‐P‐092: Six‐Month MTL Atrophy is Associated with Subsequent Memory Decline in Elderly Controls
Author(s) -
Murphy Elizabeth A.,
Holland D.,
Hagler D.J.,
Dale A.M.,
Brewer J.B.
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.106
Subject(s) - temporal lobe , atrophy , cognitive decline , superior temporal gyrus , voxel , magnetic resonance imaging , temporal cortex , middle temporal gyrus , entorhinal cortex , psychology , dementia , medicine , cognition , hippocampus , neuroscience , radiology , functional magnetic resonance imaging , epilepsy , disease
group had values that were intermediate to both MCI and HC groups (Fig. 2). CVLT-II verbal learning scores were modestly associated across subjects for radial diffusivity bilaterally (r 1⁄4 -0.23), left PWM for FA (r 1⁄4 0.26) and in right PWM for axial and mean diffusivity (r 1⁄4 -0.25) (all p < .03). Conclusions: These findings are consistent with previous results showing changes in PWM in AD and MCI compared to controls (Liu, 2009; Salat, 2010). The intermediate pattern found in the CC group suggests the potential of DTI to contribute to earlier detection of neurodegenerative changes during preclinical stages.