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P2‐018: Apathy assessment using 7‐days ambulatory actigraphy in Alzheimer's disease
Author(s) -
David Renaud,
Mulin Emmanuel,
Friedman Leah,
Zeitzer Jamie M.,
Deschaux Olivier,
Cygankiewicz Edyta,
Yesavage Jerome,
Robert Philippe H.
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.1038
Subject(s) - apathy , actigraphy , ambulatory , medicine , physical therapy , disease , psychology , psychiatry , physical medicine and rehabilitation , insomnia
cognitive impairment, have a design optimized for cognitively impaired users, be appropriate in diverse cultural settings, and suited for web-based self-administration. Computerized batteries already in existence have not been designed to cover all features. This study describes the design process of Cognitive Testing on Computer (C-TOC), an innovative tool under development that is aimed at improving diagnostic service delivery in cognitive impairment and dementia. Methods: The prototype C-TOC-version1 (CTOCv1) was created with reference to neuropsychological findings on Mild Cognitive Impairment, Alzheimer Disease (AD), and on the differentiation between AD and non-AD dementias. C-TOCv1 was evaluated and revised by a panel of clinicians with expertise in cognitive disorders. In ongoing studies, C-TOCv1 is further developed in a 3-cycle iterative design, with input from end users and from representatives of major ethnocultural groups. Individuals referred to a dementia clinic are consulted on the face validity of the tests and the usability of the computer interface. Representatives from ethnocultural groups are consulted on the validity of the tests within their own communities. Results: C-TOCv1 has been created as a mock-up of an entirely self-administered computerized test battery, which requires only use of the mouse. Test stimuli are presented visually. The aimed-for time to complete C-TOC is 30 minutes. C-TOCv1 covers the domains of episodic memory, orientation, attention, psychomotor speed, language, problem-solving and visuo-spatial construction. There are 12 tasks including Cued memory, Paired associates, Temporal orientation, Symbol digits, Trail making, Arithmetics, Sentence production and comprehension, Similarities, Pattern construction, Pattern completion, and Go-No-Go. Conclusions: CTOC is a tool developed iteratively with input from its end users and including ethnocultural considerations. By design C-TOC should have broad applicability, both for the office and the web. The uptake of C-TOC in dementia/ memory clinics could in the future reduce waiting times, optimize resource utilization, guide follow-up and help to provide diagnostic services for those living in remote locations.